SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway

SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway

Abstract Recently, evidence has suggested a regulatory role for SND1 in osteoarthritis progression. Interestingly, we found that SND1 protein expression was increased, mitochondria were shrunken and decreased in number, mitochondrial membrane potential was decreased, mitochondrial ROS production was...

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Detalhes bibliográficos
Principais autores: Shufeng Lin, Huiyang Guo, Xiaoxuan You, Zefeng Zhang, Hui Ye
Formato: Artigo
Idioma:English
Publicado em: BMC 2023-09-01
coleção:European Journal of Medical Research
Assuntos:
Osteoarthritis
SND1
Mitochondrial
Extracellular matrix
The PINK1
BECN1 pathway
Acesso em linha:https://doi.org/10.1186/s40001-023-01340-y

Internet

https://doi.org/10.1186/s40001-023-01340-y

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