Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern

Abstract: Ring sideroblasts (RS) emerge as result of aberrant erythroid differentiation leading to excessive mitochondrial iron accumulation, a characteristic feature for myelodysplastic syndromes (MDS) with mutations in the spliceosome gene SF3B1. However, RS can also be observed in patients diagno...

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Main Authors: Gerbrig Berger, Mylene Gerritsen, Guoqiang Yi, Theresia N. Koorenhof-Scheele, Leonie I. Kroeze, Marian Stevens-Kroef, Kenichi Yoshida, Yuichi Shiraishi, Eva van den Berg, Hein Schepers, Geert Huls, André B. Mulder, Seishi Ogawa, Joost H.A. Martens, Joop H. Jansen, Edo Vellenga
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920318310

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http://www.sciencedirect.com/science/article/pii/S2473952920318310

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