Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice

Longitudinal assessment of motor function following the unilateral intrastriatal 6-hydroxydopamine lesion model in mice

IntroductionDespite the widespread use of the unilateral striatal 6-hydroxydopamine (6-OHDA) lesion model in mice in recent years, the stability of behavioral deficits in the 6-OHDA striatal mouse model over time is not yet clear, raising concerns about using this model to evaluate a compound’s long...

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Bibliographic Details
Main Authors: Xiuping Sun, Xianglei Li, Ling Zhang, Yu Zhang, Xiaolong Qi, Siyuan Wang, Chuan Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Parkinson’s disease
6-OHDA
mice
gait analysis
cylinder test
rotarod test
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.982218/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.982218/full

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