RAD6 promotes chemoresistance in ovarian cancer

Mortality in ovarian cancer is predominantly due to acquired chemoresistance and tumor recurrence. UBIQUITIN CONJUGATING ENZYME E2 or RAD6 expression increases in cell lines and patient tumors in response to platinum-based chemotherapy and promotes both activation of DNA damage response pathways and...

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Bibliographic Details
Main Authors: David W. Clark, Chinnadurai Mani, Komaraiah Palle
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2017.1392403