A method to reduce ancestry related germline false positives in tumor only somatic variant calling

A method to reduce ancestry related germline false positives in tumor only somatic variant calling

Abstract Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations. When a matched germline sample is available, somatic mutations may be identified using comparative callers....

Full description

Bibliographic Details
Main Authors: Rebecca F. Halperin, John D. Carpten, Zarko Manojlovic, Jessica Aldrich, Jonathan Keats, Sara Byron, Winnie S. Liang, Megan Russell, Daniel Enriquez, Ana Claasen, Irene Cherni, Baffour Awuah, Joseph Oppong, Max S. Wicha, Lisa A. Newman, Evelyn Jaigge, Seungchan Kim, David W. Craig
Format: Article
Language:English
Published: BMC 2017-10-01
Series:BMC Medical Genomics
Subjects:
Somatic mutation
Germline variant
Next generation sequencing
Cancer
Precision medicine
Tumor purity
Online Access:http://link.springer.com/article/10.1186/s12920-017-0296-8

Internet

http://link.springer.com/article/10.1186/s12920-017-0296-8

Similar Items