Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux

Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux

<p>Abstract</p> <p>Background</p> <p>Retinoic acids regulate the reverse cholesterol transport by inducing the ATP binding cassette transporter A1 (ABCA1) dependent cholesterol efflux in macrophages, neuronal as well as intestine cells. In the present study, we aim to t...

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Bibliographic Details
Main Authors: Jiang Hong, Badralmaa Yunden, Yang Jun, Lempicki Richard, Hazen Allison, Natarajan Ven
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Lipids in Health and Disease
Subjects:
ABCA1
ATRA
retinoic acid
TO-901317
RAR
RXR
LXR
cholesterol efflux
HIV-1
CD4+ T cells
Online Access:http://www.lipidworld.com/content/11/1/69

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http://www.lipidworld.com/content/11/1/69

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