Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response

Bilirubin metabolism and UDP‐glucuronosyltransferase 1A1 variants in Asians: Pathogenic implications and therapeutic response

Abstract In the Asian general population, at least six single‐nucleotide variants (SNVs) in the UDP‐glucuronosyltransferase (UGT) 1A1 gene have been identified: −3279T>G, −53A(TA)6TAA>A(TA)7TAA, 211G>A, 686C>A, 1091C>T, and 1456T>G. Each of these six SNVs was observed in at least f...

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Bibliographic Details
Main Authors: May‐Jen Huang, Pei‐Lain Chen, Ching‐Shan Huang
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
adverse drug reaction
Gilbert's syndrome
neonatal hyperbilirubinemia
single‐nucleotide variants
UDP‐glucuronosyltransferase 1A1 gene
Online Access:https://doi.org/10.1002/kjm2.12579

Internet

https://doi.org/10.1002/kjm2.12579

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