Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis

Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis

Clonal heterogeneity detected by karyotyping is a biomarker associated with adverse prognosis in acute myeloid leukemia (AML). Constitutive activation of the phosphatidylinositol-3-kinase-Akt-mechanistic target of rapamycin (PI3K-Akt-mTOR) pathway is present in AML cells, and this pathway integrates...

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Bibliographic Details
Main Authors: Ina Nepstad, Kimberley Joanne Hatfield, Tor Henrik Anderson Tvedt, Håkon Reikvam, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
acute myeloid leukemia
PI3K
Akt
mTOR
phosphorylation
clonal heterogeneity
Online Access:http://www.mdpi.com/2072-6694/10/9/332

Internet

http://www.mdpi.com/2072-6694/10/9/332

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