Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein
Abstract Glial cytoplasmic inclusions (GCIs) containing aggregated and hyperphosphorylated α-synuclein are the signature neuropathological hallmark of multiple system atrophy (MSA). Native α-synuclein can adopt a prion conformation that self-propagates and spreads throughout the brain ultimately res...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-05-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-019-0703-9 |