Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca2+-dependent gap junction intercellular communication

Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca2+-dependent gap junction intercellular communication

Abstract. Background:. Imatinib mesylate (IM) resistance is an emerging problem for chronic myeloid leukemia (CML). Previous studies found that connexin 43 (Cx43) deficiency in the hematopoietic microenvironment (HM) protects minimal residual disease (MRD), but the mechanism remains unknown. Methods...

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Bibliographic Details
Main Authors: Xiaoping Li, Yunshuo Xiao, Xiaoqi Wang, Ruihao Huang, Rui Wang, Yi Deng, Jun Rao, Qiangguo Gao, Shijie Yang, Xi Zhang, Rongman Jia, Xiuyuan Hao
Format: Article
Language:English
Published: Wolters Kluwer 2023-01-01
Series:Chinese Medical Journal
Online Access:http://journals.lww.com/10.1097/CM9.0000000000002554

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http://journals.lww.com/10.1097/CM9.0000000000002554

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