Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics

Utilizing experimental design and desirability function in optimizing RP-HPLC method for simultaneous determination of some skeletal muscle relaxants and analgesics

Abstract An experimental design and response surface methodologies using Plackett–Burman and Box-Behnken designs were applied for selecting and optimizing the most appropriate parameters which significantly affect the separation and quantitative estimation of five skeletal muscle relaxants and four...

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Bibliographic Details
Main Authors: Ayoub N. Mozayad, Marwa A. Fouad, Ehab F. Elkady
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Experimental design
Response surface methodology
Plackett–Burman design
Box-Behnken design
Skeletal muscle relaxants
Analgesic drugs
Online Access:https://doi.org/10.1038/s41598-024-58381-4

Internet

https://doi.org/10.1038/s41598-024-58381-4

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