A Straightforward Route to Enantiopure Pyrrolizidines and Indolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool

A Straightforward Route to Enantiopure Pyrrolizidines and Indolizidines by Cycloaddition to Pyrroline N-Oxides Derived from the Chiral Pool

Enantiomerically pure, five membered cyclic nitrones, easily obtained in large amounts from protected hydroxyacids and aminoacids such as D- and L-tartaric, L-malic, and L-aspartic acids, give cycloaddition reactions with a good diastereocontrol. The adducts of L-malic and L-aspartic acids derived f...

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Bibliographic Details
Main Authors: Alberto Brandi, Valentina Fedi, Franca M. Cordero, Stefano Cicchi, Andrea Goti
Format: Article
Language:English
Published: MDPI AG 1998-12-01
Series:Molecules
Subjects:
Pyrrolizidines
pyrrolidines
stereoselective cycloaddition
glycosidase inhibitors
cyclic nitrones
review
Online Access:http://www.mdpi.com/1420-3049/4/1/1/

Internet

http://www.mdpi.com/1420-3049/4/1/1/

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