Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation

Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation

Overactivation of microglial cells seems to play a crucial role in the degeneration of dopaminergic neurons occurring in Parkinson’s disease. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) present in astrocytes secretome modulates microglial responses induced...

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Bibliographic Details
Main Authors: Julieta Mendes-Oliveira, Filipa L. Campos, Susana A. Ferreira, Diogo Tomé, Carla P. Fonseca, Graça Baltazar
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
astrocytes
conditioned media
crosstalk
dopaminergic neurons
GDNF
microglia
Online Access:https://www.mdpi.com/2073-4409/13/1/74

Internet

https://www.mdpi.com/2073-4409/13/1/74

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