ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A

Our understanding of autophagy and lysosomal function has been greatly enhanced by the discovery of natural product structures that can serve as chemical probes to reveal new patterns of signal transduction in cells. Coibamide A is a cytotoxic marine natural product that induces mTOR-independent aut...

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Bibliographic Details
Main Authors: Xuemei Wan, Jeffrey D. Serrill, Ian R. Humphreys, Michelle Tan, Kerry L. McPhail, Ian G. Ganley, Jane E. Ishmael
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Marine Drugs
Subjects:
mTOR-independent autophagy
apoptosis
coibamide A
apratoxin A
ER stress
Sec61
BiP
GRP78
Online Access:http://www.mdpi.com/1660-3397/16/3/77

Internet

http://www.mdpi.com/1660-3397/16/3/77

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