New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies.

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies.

Show other versions (1)

Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was assessed. Compound 16 was the most cytotoxic and To...

Full description

Bibliographic Details
Main Authors: Ahmed A Gaber, Mohamed Sobhy, Abdallah Turky, Wagdy M Eldehna, Samiha A El-Sebaey, Souad A El-Metwally, Abeer M El-Naggar, Ibrahim M Ibrahim, Eslam B Elkaeed, Ahmed M Metwaly, Ibrahim H Eissa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0274081

Internet

https://doi.org/10.1371/journal.pone.0274081

Similar Items