Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring <i>BRAF</i> Alterations of Distinct Functional Classes

Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring <i>BRAF</i> Alterations of Distinct Functional Classes

Background: In non-small cell lung cancer (NSCLC), BRAF class 1 alterations are effectively targeted by BRAF inhibitors. Conversely, targeted therapies have very low or absent activity in patients carrying class 2 and 3 alterations. The spectrum of BRAF alterations in NSCLC patients, and their accom...

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Bibliographic Details
Main Authors: Alessandro Di Federico, Andrea De Giglio, Francesco Gelsomino, Dario De Biase, Francesca Giunchi, Arianna Palladini, Francesca Sperandi, Barbara Melotti, Andrea Ardizzoni
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
non-small cell lung cancer
BRAF
immunotherapy
survival
genomic
non-V600
Online Access:https://www.mdpi.com/2072-6694/14/14/3472

Internet

https://www.mdpi.com/2072-6694/14/14/3472

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