Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress

Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress

AbstractTumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the phenotype and function of macrophages. Hypoxic treatment of A2780 cells was postulated to mimic...

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Bibliographic Details
Main Authors: Shu Tan, Hao Yu, Zhaocong Zhang, Yiming Liu, Ge Lou
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autoimmunity
Subjects:
Ovarian cancer
exosome
hsa-miR-1225-5p
TLR2
macrophages
wnt/β-catenin pathway
Online Access:https://www.tandfonline.com/doi/10.1080/08916934.2023.2281226

Internet

https://www.tandfonline.com/doi/10.1080/08916934.2023.2281226

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