Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress
AbstractTumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the phenotype and function of macrophages. Hypoxic treatment of A2780 cells was postulated to mimic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Autoimmunity |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/08916934.2023.2281226 |
| _version_ | 1797450002251907072 |
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| author | Shu Tan Hao Yu Zhaocong Zhang Yiming Liu Ge Lou |
| author_facet | Shu Tan Hao Yu Zhaocong Zhang Yiming Liu Ge Lou |
| author_sort | Shu Tan |
| collection | DOAJ |
| description | AbstractTumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the phenotype and function of macrophages. Hypoxic treatment of A2780 cells was postulated to mimic the tumor microenvironment, and exosomes were co-cultured with TAMs. miR-1225-5p was enriched in hypoxic exosomes and contributed to M2 macrophage polarizationby modulating Toll-like receptor 2 expression (TLR2). Furthermore, hypoxia-treated macrophages promote ovarian cancer cell viability, migration, and invasion via the wnt/β-catenin pathway. This study clarified that exosomal miR-1225-5p promotes macrophage M2-like polarization by targeting TLR2 to promote ovarian cancer, which may via the wnt/β-catenin pathway. |
| first_indexed | 2024-03-09T14:34:15Z |
| format | Article |
| id | doaj.art-fe0ca4e8066345ee9577c35907f91862 |
| institution | Directory Open Access Journal |
| issn | 0891-6934 1607-842X |
| language | English |
| last_indexed | 2024-03-09T14:34:15Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autoimmunity |
| spelling | doaj.art-fe0ca4e8066345ee9577c35907f918622023-11-27T17:03:02ZengTaylor & Francis GroupAutoimmunity0891-69341607-842X2023-12-0156110.1080/08916934.2023.2281226Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progressShu Tan0Hao Yu1Zhaocong Zhang2Yiming Liu3Ge Lou4Department of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaNangang District of Heilongjiang Provincial Hospital, Harbin, ChinaDepartment of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Gynecology Oncology, Harbin Medical University Cancer Hospital, Harbin, ChinaAbstractTumor-secreted exosomes are critical for the functional regulation of tumor-associated macrophages (TAMs). This study aimed to explore how exosomes secreted by ovarian carcinoma cells regulate the phenotype and function of macrophages. Hypoxic treatment of A2780 cells was postulated to mimic the tumor microenvironment, and exosomes were co-cultured with TAMs. miR-1225-5p was enriched in hypoxic exosomes and contributed to M2 macrophage polarizationby modulating Toll-like receptor 2 expression (TLR2). Furthermore, hypoxia-treated macrophages promote ovarian cancer cell viability, migration, and invasion via the wnt/β-catenin pathway. This study clarified that exosomal miR-1225-5p promotes macrophage M2-like polarization by targeting TLR2 to promote ovarian cancer, which may via the wnt/β-catenin pathway.https://www.tandfonline.com/doi/10.1080/08916934.2023.2281226Ovarian cancerexosomehsa-miR-1225-5pTLR2macrophageswnt/β-catenin pathway |
| spellingShingle | Shu Tan Hao Yu Zhaocong Zhang Yiming Liu Ge Lou Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress Autoimmunity Ovarian cancer exosome hsa-miR-1225-5p TLR2 macrophages wnt/β-catenin pathway |
| title | Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress |
| title_full | Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress |
| title_fullStr | Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress |
| title_full_unstemmed | Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress |
| title_short | Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress |
| title_sort | hypoxic tumour derived exosomal mir 1225 5p regulates m2 macrophage polarisation via toll like receptor 2 to promote ovarian cancer progress |
| topic | Ovarian cancer exosome hsa-miR-1225-5p TLR2 macrophages wnt/β-catenin pathway |
| url | https://www.tandfonline.com/doi/10.1080/08916934.2023.2281226 |
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