Vaccine-induced neutralizing antibody responses to seasonal influenza virus H1N1 strains are not enhanced during subsequent pandemic H1N1 infection

Vaccine-induced neutralizing antibody responses to seasonal influenza virus H1N1 strains are not enhanced during subsequent pandemic H1N1 infection

The first exposure to influenza is presumed to shape the B-cell antibody repertoire, leading to preferential enhancement of the initially formed responses during subsequent exposure to viral variants. Here, we investigated whether this principle remains applicable when there are large genetic and an...

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Bibliographic Details
Main Authors: Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, António Roldão, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
influenza
original antigenic sin
back-boosting
non-human primates
antibody response
primary response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256094/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256094/full

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