IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection

MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7 treatment supports MAIT cell reconstitution in vivo HIV-1-infected individuals and rescues their functionality in vitro. Single-nucleotide poly...

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Bibliographic Details
Main Authors: Fei Han, Muhammad Yaaseen Gulam, Yichao Zheng, Nurul Syuhada Zulhaimi, Wan Rong Sia, Dan He, Amanda Ho, Leila Hadadi, Zhenyu Liu, Peiwu Qin, Peter E. Lobie, Adeeba Kamarulzaman, Lin-Fa Wang, Johan K. Sandberg, Sharon R. Lewin, Reena Rajasuriar, Edwin Leeansyah
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
MAIT cells
HIV-1
IL-7
CD127 (IL7Ra) gene
antiretroviral (ARV) therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.985385/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.985385/full

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