Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells

Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells

Abstract Background An HIV cure has not yet been achieved because latent viral reservoirs persist, particularly in resting CD4+ T lymphocytes. In vitro, it is difficult to infect resting CD4+ T cells with HIV-1, but infections readily occur in vivo. Endothelial cells (EC) line the lymphatic vessels...

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Bibliographic Details
Main Authors: Meghan Schilthuis, Seth Verkaik, Mackenzie Walhof, Andrew Philipose, Olivia Harlow, Derrick Kamp, Bo Ram Kim, Anding Shen
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Virology Journal
Subjects:
HIV
Resting CD4+ T
Latent infection
Lymphatic endothelial cells
Viral reservoir
Online Access:http://link.springer.com/article/10.1186/s12985-018-1068-6

Internet

http://link.springer.com/article/10.1186/s12985-018-1068-6

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