Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1
<p>Abstract</p> <p>Skp2 over-expression has been observed in many human cancers. However, the mechanisms underlying elevated Skp2 expression have remained elusive. We recently reported that Akt1, but not Akt2, directly controls Skp2 stability by interfering with its association wit...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-06-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/4/1/11 |