Circulating Exosomes from Septic Mice Activate NF-κB/MIR17HG Pathway in Macrophages

Circulating Exosomes from Septic Mice Activate NF-κB/MIR17HG Pathway in Macrophages

Circulating exosomes derived from polymicrobial sepsis contain various non-coding RNAs and proteins. Isobaric tags for a relative or absolute quantitation proteomic analysis of the exosomal content revealed 70 dysregulated proteins in the circulating exosomes from septic mice. Next-generation sequen...

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Bibliographic Details
Main Authors: Shao-Chun Wu, Cheng-Shyuan Rau, Yi-Chan Wu, Chia-Jung Wu, Chia-Wen Tsai, Lien-Hung Huang, Chia-Wei Lin, Tsu-Hsiang Lu, Ming-Yu Yang, Ching-Hua Hsieh
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomedicines
Subjects:
sepsis
exosome
nuclear factor-kappa B (NF-κB)
long non-coding RNA (lncRNA)
miR-17-92a-1 cluster host gene (MIR17HG)
pull-down assay
Online Access:https://www.mdpi.com/2227-9059/12/3/534

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https://www.mdpi.com/2227-9059/12/3/534

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