Atto488-Agitoxin 2—A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site

Atto488-Agitoxin 2—A Fluorescent Ligand with Increased Selectivity for Kv1.3 Channel Binding Site

Fluorescently labeled peptide blockers of ion channels are useful probes in studying the localization and functioning of the channels and in the performance of a search for new channel ligands with bioengineering screening systems. Here, we report on the properties of Atto488-agitoxin 2 (A-AgTx2), a...

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Bibliographic Details
Main Authors: Kristina R. Denisova, Nikita A. Orlov, Sergey A. Yakimov, Mikhail P. Kirpichnikov, Alexey V. Feofanov, Oksana V. Nekrasova
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Bioengineering
Subjects:
agitoxin 2
Kv1.3 channel
pore blocker
fluorescent ligand
affinity
KcsA
Online Access:https://www.mdpi.com/2306-5354/9/7/295

Internet

https://www.mdpi.com/2306-5354/9/7/295

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