Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target

To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater resistance to pneumococcal pneumonia, seen as greater bacterial clearance, dimini...

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Bibliographic Details
Main Authors: Zhiping Yang, Yuh-Chin T Huang, Henry Koziel, Rini de Crom, Hartmut Ruetten, Paulus Wohlfart, Reimar W Thomsen, Johnny A Kahlert, Henrik Toft Sørensen, Szczepan Jozefowski, Amy Colby, Lester Kobzik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-10-01
Series:eLife
Subjects:
macrophage
innate immunity
pneumonia
nitric oxide
bacteria
gender
Online Access:https://elifesciences.org/articles/03711

Internet

https://elifesciences.org/articles/03711

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