SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

Summary: Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood. Evidence suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein or its fragments are rel...

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Bibliographic Details
Main Authors: Fabricia L. Fontes-Dantas, Gabriel G. Fernandes, Elisa G. Gutman, Emanuelle V. De Lima, Leticia S. Antonio, Mariana B. Hammerle, Hannah P. Mota-Araujo, Lilian C. Colodeti, Suzana M.B. Araújo, Gabrielle M. Froz, Talita N. da Silva, Larissa A. Duarte, Andreza L. Salvio, Karina L. Pires, Luciane A.A. Leon, Claudia Cristina F. Vasconcelos, Luciana Romão, Luiz Eduardo B. Savio, Jerson L. Silva, Robson da Costa, Julia R. Clarke, Andrea T. Da Poian, Soniza V. Alves-Leon, Giselle F. Passos, Claudia P. Figueiredo
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723002000

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http://www.sciencedirect.com/science/article/pii/S2211124723002000

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