Recombinant Alpha-1 Antitrypsin as Dry Powder for Pulmonary Administration: A Formulative Proof of Concept

Recombinant Alpha-1 Antitrypsin as Dry Powder for Pulmonary Administration: A Formulative Proof of Concept

Alpha-1 antitrypsin (AAT) deficiency is a genetic disorder associated with pulmonary emphysema and bronchiectasis. Its management currently consists of weekly infusions of plasma-purified human AAT, which poses several issues regarding plasma supplies, possible pathogen transmission, purification co...

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Bibliographic Details
Main Authors: Annalisa Bianchera, Esraa’a Alomari, Annalisa Michielon, Gianluca Bazzoli, Nicoletta Ronda, Giovanni Pighini, Ilaria Zanotti, Carmine Giorgio, Andrea Mozzarelli, Ruggero Bettini, Stefano Bruno
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceutics
Subjects:
alpha-1 antitrypsin
recombinant protein
pulmonary drug delivery
inhalable dry powder
Online Access:https://www.mdpi.com/1999-4923/14/12/2754

Internet

https://www.mdpi.com/1999-4923/14/12/2754

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