Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats

Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats

High-ethanol intake induces a neuroinflammatory response, which has been proposed as responsible for the maintenance of chronic ethanol consumption. Neuroinflammation decreases glutamate transporter (GLT-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic...

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Bibliographic Details
Main Authors: Francisca Villavicencio-Tejo, Osvaldo Flores-Bastías, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
fibrates
alcohol use disorder
alcoholism
treatment
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.653175/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.653175/full

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