Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice

Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease worldwide, with no effective therapies available. Discovering lead compounds from herb medicine might be a valuable strategy for the treatment of NASH. Here, we discovered Alisol B, a natural compound isolated from <i>Alism...

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Bibliographic Details
Main Authors: Zhuohui Zhao, Zhen-Tao Deng, Suling Huang, Mengmeng Ning, Ying Feng, Yu Shen, Qin-Shi Zhao, Ying Leng
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Nutrients
Subjects:
Alisol B
non-alcoholic steatohepatitis
RARα
CD36
Online Access:https://www.mdpi.com/2072-6643/14/12/2411

Internet

https://www.mdpi.com/2072-6643/14/12/2411

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