Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations

Speckle-type POZ protein (SPOP) is a substrate adaptor in the ubiquitin proteasome system, and plays important roles in cell-cycle control, development, and cancer pathogenesis. SPOP forms linear higher-order oligomers following an isodesmic self-association model. Oligomerization is essential for S...

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Bibliographic Details
Main Authors: F Emil Thomasen, Matthew J Cuneo, Tanja Mittag, Kresten Lindorff-Larsen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
self-assembly
small-angle x-ray scattering
protein structure
isodesmic
molecular simulations
Online Access:https://elifesciences.org/articles/84147

Internet

https://elifesciences.org/articles/84147

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