Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

Evolution from genetics to phenotype: reinterpretation of NSCLC plasticity, heterogeneity, and drug resistance

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. Targeted therapy is beneficial in most cases, but the development of drug resistance stands as an obstacle to good prognosis. Multiple mechanisms were explored such as genetic alterations, activation of bypass signaling, a...

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Bibliographic Details
Main Authors: Yingjiao Xue, Shenda Hou, Hongbin Ji, Xiangkun Han
Format: Article
Language:English
Published: Oxford University Press 2016-10-01
Series:Protein & Cell
Subjects:
lung cancer
plasticity
heterogeneity
drug resistance
phenotypic transition
Online Access:http://link.springer.com/article/10.1007/s13238-016-0330-1

Internet

http://link.springer.com/article/10.1007/s13238-016-0330-1

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