Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo

Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo

Introduction of α-cyano α,β-unsaturated carbonyl moiety into natural cyclic compounds markedly improves their bioactivities, including inhibitory potential against tumor growth and metastasis. Previously, we showed that cyano enone-bearing derivatives of 18βH-glycyrrhetinic (GA) and deoxycholic acid...

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Bibliographic Details
Main Authors: Andrey V. Markov, Kirill V. Odarenko, Aleksandra V. Sen’kova, Oksana V. Salomatina, Nariman F. Salakhutdinov, Marina A. Zenkova
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
epithelial-mesenchymal transition
tumor
metastasis
triterpenoids
natural compounds
soloxolone methyl
Online Access:https://www.mdpi.com/1420-3049/25/24/5925

Internet

https://www.mdpi.com/1420-3049/25/24/5925

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