Small molecule quercetin binds MALAT1 triplex and modulates its cellular function

The triple-helix structure at the 3′ end of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA, has been considered to be a target for modulating the oncogenic functions of MALAT1. This study examines the binding of quercetin—a known triplex binding molecule—to th...

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Bibliographic Details
Main Authors: Isha Rakheja, Asgar Hussain Ansari, Arjun Ray, Dheeraj Chandra Joshi, Souvik Maiti
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122002591