Differential Targeting of Gr-MDSCs, T Cells and Prostate Cancer Cells by Dactolisib and Dasatinib

Differential Targeting of Gr-MDSCs, T Cells and Prostate Cancer Cells by Dactolisib and Dasatinib

Granulocytic myeloid-derived suppressor cells (Gr-MDSCs) promote immune evasion and resistance to immunotherapeutics in a variety of malignancies. Our previous study showed that dual PI3K/mTOR inhibitor Dactolisib impaired the viability and immunosuppressive function of Gr-MDSCs, and significantly s...

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Bibliographic Details
Main Authors: Guoqiang Liu, Zhijian Jin, Xin Lu
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
granulocytic myeloid-derived suppressor cells
immune checkpoint blockade
combination immunotherapy
castration-resistant prostate cancer
Dactolisib
Dasatinib
Online Access:https://www.mdpi.com/1422-0067/21/7/2337

Internet

https://www.mdpi.com/1422-0067/21/7/2337

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