Molecular Docking and Fluorescence Characterization of Benzothieno[3,2-d]pyrimidin-4-one Sulphonamide Thio-Derivatives, a Novel Class of Selective Cyclooxygenase-2 Inhibitors

Molecular Docking and Fluorescence Characterization of Benzothieno[3,2-d]pyrimidin-4-one Sulphonamide Thio-Derivatives, a Novel Class of Selective Cyclooxygenase-2 Inhibitors

The aims of this study were: (i) to explore the structure-activity relationship of some new anti-inflammatory benzothieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives 1–11; and (ii) to evaluate the possibility of using the most active compounds as fluorescent probes to determine tumours or...

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Bibliographic Details
Main Authors: Mariarita Barone, Giovanna Pannuzzo, Andrea Santagati, Alfio Catalfo, Guido De Guidi, Venera Cardile
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Molecules
Subjects:
anti-inflammatory
antipyrine
cancer detection
COX-2
fluorescence
Online Access:http://www.mdpi.com/1420-3049/19/5/6106

Internet

http://www.mdpi.com/1420-3049/19/5/6106

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