A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.

<h4>Background</h4>Height has been associated with many clinical traits but whether such associations are causal versus secondary to confounding remains unclear in many cases. To systematically examine this question, we performed a Mendelian Randomization-Phenome-wide association study (...

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Bibliographic Details
Main Authors: Sridharan Raghavan, Jie Huang, Catherine Tcheandjieu, Jennifer E Huffman, Elizabeth Litkowski, Chang Liu, Yuk-Lam A Ho, Haley Hunter-Zinck, Hongyu Zhao, Eirini Marouli, Kari E North, VA Million Veteran Program, Ethan Lange, Leslie A Lange, Benjamin F Voight, J Michael Gaziano, Saiju Pyarajan, Elizabeth R Hauser, Philip S Tsao, Peter W F Wilson, Kyong-Mi Chang, Kelly Cho, Christopher J O'Donnell, Yan V Sun, Themistocles L Assimes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010193