Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice

Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice

Background: Substantial data have implicated microglial-driven neuroinflammation in Parkinson’s disease (PD) and environmental toxicants have been long expected as triggers of such inflammatory processes. Of course, these environmental insults act in the context of genetic vulnerability factors and...

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Bibliographic Details
Main Authors: Zach Dwyer, Chris Rudyk, Divya Situt, Sheryl Beauchamp, Jawaria Abdali, Anu Dinesh, Nathalie Legancher, Hongyu Sun, Michael Schlossmacher, Shawn Hayley
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Microglia
Neurodegeneration
Parkinson’s
LRRK2
LPS
Toxicant
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300442

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http://www.sciencedirect.com/science/article/pii/S2666354620300442

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