Schizophrenia Risk Mediated by microRNA Target Genes Overlapped by Genome-Wide Rare Copy Number Variation in 22q11.2 Deletion Syndrome

Schizophrenia Risk Mediated by microRNA Target Genes Overlapped by Genome-Wide Rare Copy Number Variation in 22q11.2 Deletion Syndrome

The 22q11.2 deletion is associated with >20-fold increased risk for schizophrenia. The presence of gene DGCR8 in the 22q11.2 deletion region has suggested microRNA (miRNA) dysregulation as possibly contributing to this risk. We therefore investigated the role of miRNA target genes in the cont...

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Bibliographic Details
Main Authors: Shengjie Ying, Tracy Heung, Zhaolei Zhang, Ryan K. C. Yuen, Anne S. Bassett
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Genetics
Subjects:
schizophrenia
pathway enrichment analysis
neurodevelopmental disorders
DiGeorge syndrome
model system
DGCR8
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.812183/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.812183/full

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