Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes

Activation of endothelial NO synthase and P2X7 receptor modification mediates the cholinergic control of ATP-induced interleukin-1β release by mononuclear phagocytes

ObjectiveThe pro-inflammatory cytokine interleukin-1β (IL-1β) plays a central role in host defense against infections. High systemic IL-1β levels, however, promote the pathogenesis of inflammatory disorders. Therefore, mechanisms controlling IL-1β release are of substantial clinical interest. Recent...

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Bibliographic Details
Main Authors: Katrin Richter, Nilay Asci, Vijay K. Singh, Sanaria Hawro Yakoob, Marion Meixner, Anna Zakrzewicz, Juliane Liese, Andreas Hecker, Sigrid Wilker, Sabine Stumpf, Klaus-Dieter Schlüter, Marius Rohde, Axel Gödecke, Winfried Padberg, Ivan Manzini, Günther Schmalzing, Veronika Grau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
inflammation
P2X7 receptor
CHRNA7
CHRNA9
CHRNA10
endothelial NO synthase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140592/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1140592/full

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