Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding

Abstract Lewy-body pathology with aggregation of abnormal conformations of the protein alpha-synuclein (α-Syn) represent the histopathological hallmarks of Parkinson’s disease (PD). Genetic prototypes such as PD due to mutations in the alpha-synuclein gene (SNCA) offer the opportunity to evaluate α-...

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Bibliographic Details
Main Authors: Isabel Wurster, Corinne Quadalti, Marcello Rossi, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Christian la Fougere, Kathrin Doppler, Thomas Gasser, Benjamin Bender, Piero Parchi, Kathrin Brockmann
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00379-8

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https://doi.org/10.1038/s41531-022-00379-8

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