Comparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression

Comparison of anti-cancer effects of novel protein disulphide isomerase (PDI) inhibitors in breast cancer cells characterized by high and low PDIA17 expression

Abstract Background Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear. Methods The content of PDI isoforms in 22 cancer cells lines was investigated using LC–MS/MS-based p...

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Bibliographic Details
Main Authors: Anna Kurpińska, Joanna Suraj-Prażmowska, Marta Stojak, Joanna Jarosz, Łukasz Mateuszuk, Ewa Niedzielska-Andres, Magdalena Smolik, Joanna Wietrzyk, Ivars Kalvins, Maria Walczak, Stefan Chłopicki
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Cancer Cell International
Subjects:
Protein disulphide isomerases
Anterior gradient 2 (AGR2, PDIA17)
Novel PDI inhibitors
Endoplasmic reticulum (ER)–resident protein 57 (ERP57, PDIA3)
Protein disulphide isomerase A1 (prolyl 4-hydroxylase subunit beta
P4HB, PDIA1)
Online Access:https://doi.org/10.1186/s12935-022-02631-w

Internet

https://doi.org/10.1186/s12935-022-02631-w

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