The Novel <i>gem</i>-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells

The Novel <i>gem</i>-Dihydroperoxide 12AC3O Suppresses High Phosphate-Induced Calcification via Antioxidant Effects in p53LMAco1 Smooth Muscle Cells

The excessive intake of phosphate (Pi), or chronic kidney disease (CKD), can cause hyperphosphatemia and eventually lead to ectopic calcification, resulting in cerebrovascular diseases. It has been reported that reactive oxygen species (ROS), induced by high concentrations of Pi loading, play a key...

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Bibliographic Details
Main Authors: Naoko Takase, Masatoshi Inden, Shunsuke Hirai, Yumeka Yamada, Hisaka Kurita, Mitsumi Takeda, Eiji Yamaguchi, Akichika Itoh, Isao Hozumi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
phosphate
reactive oxygen species
calcification
dihydroperoxides
Online Access:https://www.mdpi.com/1422-0067/21/13/4628

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https://www.mdpi.com/1422-0067/21/13/4628

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