Tankyrase inhibition sensitizes cells to CDK4 blockade.

Tankyrase inhibition sensitizes cells to CDK4 blockade.

Tankyrase (TNKS) 1/2 are positive regulators of WNT signaling by controlling the activity of the ß-catenin destruction complex. TNKS inhibitors provide an opportunity to suppress hyperactive WNT signaling in tumors, however, they have shown limited anti-proliferative activity as a monotherapy in hum...

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Bibliographic Details
Main Authors: Miguel Foronda, Yusuke Tarumoto, Emma M Schatoff, Benjamin I Leach, Bianca J Diaz, Jill Zimmerman, Sukanya Goswami, Michael Shusterman, Christopher R Vakoc, Lukas E Dow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226645&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226645&type=printable

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