In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.B79) is essential for viral replication. High throughput in silico/in vitro screening using a focused set of known cysteine protease inhibitors identified two epoxysuccinyl prodrugs, E64d and...

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Bibliographic Details
Main Authors: Xin Hu, Elaine Morazzani, Jaimee R. Compton, Moeshia Harmon, Veronica Soloveva, Pamela J. Glass, Andres Dulcey Garcia, Juan J. Marugan, Patricia M. Legler
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Viruses
Subjects:
alphavirus
nsP2 cysteine protease
irreversible
reversible
inhibitor
oxindole
Online Access:https://www.mdpi.com/1999-4915/15/7/1503

Internet

https://www.mdpi.com/1999-4915/15/7/1503

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