Precise genome-wide mapping of single nucleosomes and linkers in vivo

Precise genome-wide mapping of single nucleosomes and linkers in vivo

Abstract We developed a chemical cleavage method that releases single nucleosome dyad-containing fragments, allowing us to precisely map both single nucleosomes and linkers with high accuracy genome-wide in yeast. Our single nucleosome positioning data reveal that nucleosomes occupy preferred positi...

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Bibliographic Details
Main Authors: Răzvan V. Chereji, Srinivas Ramachandran, Terri D. Bryson, Steven Henikoff
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Genome Biology
Subjects:
Chemical cleavage mapping
Linker quantization
Biophysical modeling
Online Access:http://link.springer.com/article/10.1186/s13059-018-1398-0

Internet

http://link.springer.com/article/10.1186/s13059-018-1398-0

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