Enrichment of T-cell proliferation and memory gene signatures of CD79A/CD40 costimulatory domain potentiates CD19CAR-T cell functions

Enrichment of T-cell proliferation and memory gene signatures of CD79A/CD40 costimulatory domain potentiates CD19CAR-T cell functions

CD19 chimeric antigen receptor (CAR) T-cells have demonstrated remarkable outcomes in B-cell malignancies. Recently, the novel CD19CAR-T cells incorporated with B-cell costimulatory molecules of CD79A/CD40 demonstrated superior antitumor activity in the B-cell lymphoma model compared with CD28 or 4-...

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Bibliographic Details
Main Authors: Socheatraksmey Ung, Pongsakorn Choochuen, Wannakorn Khopanlert, Kajornkiat Maneechai, Surasak Sangkhathat, Seitaro Terakura, Jakrawadee Julamanee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
gene expression profiling
CAR-T cell
CD79A/CD40
costimulatory domain
CD19
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064339/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1064339/full

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