Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

This chapter explores the possibility that capacitation and apoptosis are linked processes joined by their common dependence on the continued generation of reactive oxygen species (ROS). According to this model capacitation is initiated in spematozoa following their release into the female reproduct...

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Bibliographic Details
Main Authors:	Robert J Aitken, Mark A Baker, Brett Nixon
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2015-01-01
Series:	Asian Journal of Andrology
Subjects:	gene regulation Musashi Musashi-1 Musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation cell fate cell stress importin karyopherin nucleocytoplasmic transport spermatid spermatocyte artificial insemination biomarker fertility fertilization flow cytometry infertility nanotechnology oocyte activation Postacrosomal Sheath WWI Domain Binding Protein sperm SPTRX3 thioredoxin ubiquitin ATP binding cassette transporters albumin high-density lipoprotein lipid rafts membrane fluidity membrane microdomains membrane packing oxysterols reverse cholesterol transport sterol transporters egg heat shock protein A2 molecular chaperone sperm-egg interactions dehydrogenases oxidases peroxiredoxins reactive oxygen species spermatozoa thiols thioredoxins antigen-presenting cells autoimmunity dendritic cells epididymis macrophages peripheral tolerance sperm maturation genomics male infertility proteomics sperm chromatin sperm epigenetics sperm DNA damage paternal genome offspring chemotaxis rheotaxis sperm behavior sperm motility thermotaxis apoptosis sperm capacitation
Online Access:	http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=633;epage=639;aulast=Aitken

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2015;volume=17;issue=4;spage=633;epage=639;aulast=Aitken

Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?

Internet

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