IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes

ABSTRACT Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent...

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Bibliographic Details
Main Authors: Cécile Apert, Paola Romagnoli, Joost P. M. van Meerwijk
Format: Article
Language:English
Published: Oxford University Press 2017-05-01
Series:Protein & Cell
Subjects:
regulatory T cells
thymus
differentiation
IL-2
IL-15
Online Access:http://link.springer.com/article/10.1007/s13238-017-0425-3

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http://link.springer.com/article/10.1007/s13238-017-0425-3

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