Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes

Size and Flexibility Define the Inhibition of the H3N2 Influenza Endonuclease Enzyme by Calix[n]arenes

Inhibition of H3N2 influenza PA endonuclease activity by a panel of anionic calix[n]arenes and β-cyclodextrin sulfate has been studied. The joint experimental and theoretical results reveal that the larger, more flexible and highly water-soluble sulfonato-calix[n]arenes have high inhibitory...

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Bibliographic Details
Main Authors: Yannick Tauran, José Pedro Cerón-Carrasco, Moez Rhimi, Florent Perret, Beomjoon Kim, Dominique Collard, Anthony W. Coleman, Horacio Pérez-Sánchez
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Antibiotics
Subjects:
enzyme inhibitors
calix[n]arene
endonuclease
anti-viral activity
H3N2 virus
molecular docking
Online Access:https://www.mdpi.com/2079-6382/8/2/73

Internet

https://www.mdpi.com/2079-6382/8/2/73

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