Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia

Background Type I interferons (IFN-Is), secreted by hematopoietic cells, drive immune surveillance of solid tumors. However, the mechanisms of suppression of IFN-I-driven immune responses in hematopoietic malignancies including B-cell acute lymphoblastic leukemia (B-ALL) are unknown.Methods Using hi...

Full description

Bibliographic Details
Main Authors: Anil Kumar, Min Huang, Norman J. Lacayo, Holden T. Maecker, Stephen J. Forman, Srividya Swaminathan, Caroline Duault, Jianhua Yu, Steven T. Rosen, Anthony Chan, Martin Carroll, Adeleh Taghi Khani, Soraya Aramburo, Ashly Sanchez Ortiz, Sung June Lee, Tinisha McDonald, Kathleen M. Sakamoto, Christian Hurtz, Sarah K. Tasian, Lucy Ghoda, Guido Marcucci, Zhaohui Gu, Saro Armenian, Shai Izraeli, Chun-Wei Chen, Michael A. Caligiuri
Format: Article
Language:English
Published: BMJ Publishing Group 2023-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/5/e006649.full

Internet

https://jitc.bmj.com/content/11/5/e006649.full

Similar Items